Fig. 2
From: Myelination- and immune-mediated MR-based brain network correlates
Structural and anatomical white matter changes during de- and remyelination in the cuprizone model. Example immunohistochemical images of coronal mouse slices containing the corpus callosum (CC) in control conditions (1st column), at 6 weeks after starting the cuprizone diet (cupri 6 weeks—full demyelination, 2nd column), and at full remyelination 6 weeks after reintroduction of normal food (3rd column). On the right of each panel, bar graphs show quantifications of changes. Stained for: a myelin specific marker PLP; b astrocytic specific marker GFAP; c exemplary T2-weighted images obtained in living mice during a longitudinal MRI scan. Pictures show frontal part of mouse brain containing neocortex and CC from control, cupri 6 weeks and remy 6 weeks mice. Bar graph shows the ratio calculated between the intensity of the myelin signal observed in Cx (SICx) and CC (SICC). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001