Fig. 2

ATO alleviates demyelination in the spinal cord of EAE mice. Representative LFB staining sections (a) and demyelination score (c) of spinal cord (n = 9). Areas enclosed within black squares are magnified on the right. b Representative immunofluorescent staining sections of MBP in spinal cord. Areas enclosed within green squares are magnified on the right. d Mean fluorescence intensity analysis of MBP in b (n = 3). e The mRNA level of MBP in spinal cord was quantified by qRT-PCR (n = 3). f The protein level of MBP in spinal cord was analyzed by western blot. Data are representative of three independent experiments. *p < 0.05, ***p < 0.001, and ****p < 0.0001 vs. the control group; #p < 0.05 and ###p < 0.001 the EAE+ATO group vs. the EAE group