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Table 4 Effects of PLX on body weight, locomotor activity in a new cage, and voluntary wheel running response to LPS. F values from 2 (PLX diet vs. control diet) × time ANOVA for body weight and voluntary wheel running before LPS treatment, from 2 (PLX diet vs. control diet) × 2 (LPS vs. control) ANOVA for locomotor activity in a new cage, and from 2 (PLX diet vs. control diet) × 2 (LPS vs. control) ANOVA with 6 mice/group with time as a repeated factor for body weight loss and voluntary wheel running

From: Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

 

PLX

LPS

PLX × LPS

Time

PLX × time

LPS × time

PLX × LPS × time

Body weight

F(1, 22) = 0.200 NS

  

F(6, 132) = 3.85**

F(6, 132) = 1.86 NS

  

LPS effect on body weight

F(1, 20) = 0.342 NS

F(1, 20) = 1.14 NS

F(1, 20) = 1.31 NS

F(2, 40) = 65.2***

F(2, 40) = 1.57 NS

F(2, 40) = 31.0***

F(2, 40) = 1.57 NS

LPS effect on activity new cage

F(1, 20) = 0.186 NS

F(1, 20) = 16.8***

F(1, 20) = 1.36 NS

    

Pre-LPS wheel running

F(1, 22) = 18.4***

  

F(6, 132) = 44.3***

F(6, 132) = 0.803 NS

  

LPS effect on wheel running

F(1, 20) = 275***

F(1, 20) = 7.45*

F(1, 20) = 1.67 NS

 

F(5, 100) = 4.24**

F(5, 100) = 25.8***

F(5, 100) = 7.90***

  1. NS non-significant
  2. *p < 0.05, **p < 0.01, ***p < 0.001