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Table 6 Effects of microglial depletion by diphtheria toxin in Cx3cr1-Dtr rats on the effects of LPS on body weight and activity and center entries in the open-field test. Body weight differences post-DT are assessed by a Student t test, comparing all wt with all Cx3cr1-Dtr rats (16–17 rats per group). F values from 2 (diphtheria toxin vs. control) × 2 (LPS vs. control) and time as the repeated measures ANOVA with 7–9 rats/group

From: Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

  DT LPS DT × LPS Time DT × time LPS × time DT × LPS × time
Body weight t(31) = 16.6***       
LPS effect on body weight F(1, 28) = 0.03 NS F(1, 28) = 24.3*** F(1, 28) = 0.12 NS     
LPS effect on activity in the open field F(1, 28) = 20.7*** F(1, 28) = 21.6*** F(1, 28) = 5.21* F(1, 28) = 0.01 NS F(1, 28) = 1.19 NS F(1, 28) = 1.84 NS F(1, 28) = 1.44 NS
LPS effect on center entries in the open field F(1, 26) = 3.55 NS F(1, 26) = 12.2** F(1, 26) = 0.08 NS F(1, 26) = 8.80** F(1, 26) = 0.01 NS F(1, 26) = 4.68* F(1, 26) = 0.24 NS
  1. NS non-significant
  2. *p < 0.05, **p < 0.01, ***p < 0.001