Skip to main content

Table 6 Effects of microglial depletion by diphtheria toxin in Cx3cr1-Dtr rats on the effects of LPS on body weight and activity and center entries in the open-field test. Body weight differences post-DT are assessed by a Student t test, comparing all wt with all Cx3cr1-Dtr rats (16–17 rats per group). F values from 2 (diphtheria toxin vs. control) × 2 (LPS vs. control) and time as the repeated measures ANOVA with 7–9 rats/group

From: Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

 

DT

LPS

DT × LPS

Time

DT × time

LPS × time

DT × LPS × time

Body weight

t(31) = 16.6***

      

LPS effect on body weight

F(1, 28) = 0.03 NS

F(1, 28) = 24.3***

F(1, 28) = 0.12 NS

    

LPS effect on activity in the open field

F(1, 28) = 20.7***

F(1, 28) = 21.6***

F(1, 28) = 5.21*

F(1, 28) = 0.01 NS

F(1, 28) = 1.19 NS

F(1, 28) = 1.84 NS

F(1, 28) = 1.44 NS

LPS effect on center entries in the open field

F(1, 26) = 3.55 NS

F(1, 26) = 12.2**

F(1, 26) = 0.08 NS

F(1, 26) = 8.80**

F(1, 26) = 0.01 NS

F(1, 26) = 4.68*

F(1, 26) = 0.24 NS

  1. NS non-significant
  2. *p < 0.05, **p < 0.01, ***p < 0.001