Skip to main content
Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses

Fig. 10

Pharmacological blocking NLRP3 inflammasome activation attenuates astrocyte and microglial activation in SCDH of CPIP rats. a Representative photos of ipsilateral SCDH stained with GFAP antibody showing astrocytes from Sham+Veh, CPIP+Veh, and CPIP+MCC950 group. Scale bar = 100 μm. b Summary of the normalized fluorescence intensity (%) of GFAP staining in ipsilateral SCDH. n = 5 rats/group. c Summary of the number of astrocytes observed in ipsilateral SCDH per observation field. n = 5 rats/group. d Representative photos of ipsilateral SCDH stained with OX42 antibody showing microglia from Sham+Veh, CPIP+Veh, and CPIP+MCC950 group. Scale bar = 100 μm. e Summary of the normalized fluorescence intensity (%) of OX42 staining in ipsilateral SCDH. n = 6 rats/group. f Summary of the number of microglia observed in ipsilateral SCDH per observation field. n = 6 rats/group. **p < 0.01 vs. Sham+Veh group. #p < 0.05, ##p < 0.01 vs. CPIP+Veh group. One-way ANOVA followed by Tukey’s post hoc test was used for comparison

Back to article page