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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

Fig. 2

Intranasal administration of human recombinant NT-4 improved short-term function at 72 h post GMH. a, b Negative geotaxis test. c Righting reflex test showed that the medium dose (0.1 mg/kg) and high dose (0.3 mg/kg) of rh-NT-4 significantly improved neurological function compared to vehicle-treated pups during the first 3 days after GMH. Asterisk indicates p < 0.05 vs Sham, number sign indicates p < 0.05 vs GMH + vehicle, dollar sign indicates p < 0.05 vs low dose (0.03 mg/kg) group, one-way ANOVA, Tukey’s test, n = 6/group. Data is presented as mean ± SD

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