Fig. 6

Selective inhibition of TrkB and PI3K in microglia abolished the effect of rh-NT-4 on inhibiting neuroinflammation at 3 days after GMH. a Representative images of Western blot bands. b-g Quantitative analyses of NT-4, phosphorylated TrkB, PI3K, phosphorylated Akt, FoxO1, IL-6 at day 3 after GMH. Asterisk indicates p < 0.05 vs sham, number sign indicates p < 0.05 vs GMH + vehicle, dollar sign indicates p < 0.05 vs GMH + NT-4, commercial At indicates p < 0.05 vs GMH + ANA-12, ampersand indicates p < 0.05 vs GMH + LY-294002. One-way ANOVA, Tukey’s test, n = 6/group. Data is presented as mean ± SD