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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

Fig. 7

FoxO1 activating CRISPR in microglia abolished the effect of rh-NT-4 on inhibiting neuroinflammation at day 3 after GMH. a Representative images of Western blot bands. b-g Quantitative analyses of NT-4, phosphorylated TrkB, PI3K, phosphorylated Akt, FoxO1, IL-6 at day 3 after GMH. Asterisk indicates p < 0.05 vs sham, number sign indicates p < 0.05 vs GMH + vehicle, dollar sign indicates p < 0.05 vs GMH + NT-4, % p < 0.05 vs GMH + FoxO1 CRISPR. One-way ANOVA, Tukey’s test, n = 6/group. Data is presented as mean ± SD

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