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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

Fig. 5

Blockade of ERK abolished the preventive effect of DHLA. a Effect of DHLA on body weight changes. b–e Depression-like behaviors were assessed by forced swimming test (b) and open field test (c–e). The data were expressed as mean ± SEM (n = 6). **P < 0.01; ****P < 0.0001 versus the control group. ##P < 0.01; ###P < 0.001; ####P < 0.0001 versus the LPS group. &P < 0.05; &&P < 0.01 versus the LPS + DHLA group. The Shapiro-Wilk test results showed that all the data are normally distributed (p > 0.05)

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Journal of Neuroinflammation

ISSN: 1742-2094