Fig. 4

Chronic HFD feeding attenuated the suppression of LPS-induced behavior in mice. a Representative images from EPM analysis showing the walking track of animals from the four groups (left panel). The time spent in the open arms (seconds), number of entries into the open arms, and total distance traveled were measured. b The representative images indicate the walking tracks of animals from the four groups in the OFT (left panel). The time spent in the center of the OFT (seconds), number of entries into the center of the OFT, and total walking distance were measured. The data are presented as the mean + SEM. The data shown in a and b are presented as the mean + SEM of 6 animals from each group a, b. **p < 0.01, ***p < 0.001 versus the chow-LPS group; ^###p < 0.001 versus the HFD-LPS group