Fig. 1

FXR was upregulated in neurons after cerebral ischemia. a Western blot of FXR expression in the mouse brain at different time points after tMCAO. Data are presented as mean ± SD, n = 6–8/group, **p < 0.01, ***p < 0.001. b Confocal imaging showed the co-localization of FXR (green) with neurons (NeuN, red), microglia (Iba-1, red), astrocytes (GFAP, red), and endothelial cells (CD31, red) in the peri-infarct area at 3 days after stroke, Bar = 50 μm and 10 μm, respectively