Fig. 2

Knockout of FXR reduced brain infarct volume and promoted neurobehavioral recovery in mice. a Experimental scheme. b Representative cresyl violet-stained brain sections at 3 days of sham mice (Sham group), stroke mice treated with vehicle (vehicle group), and FXR knockout stroke mice (FXR KO group). n = 4–7/group. The brain infarct area was circled by the dashed line, and bar graph showed the quantitative comparison of the infarct volume. Data are presented as mean ± SD. **p < 0.01. c Brain atrophy at 14 days in sham group, vehicle group, and FXR KO group were also detected by Cresyl violet, the dashed line represented brain atrophy. Bar graph showed the brain atrophy volume. Data are presented as mean ± SD. **p < 0.01. Neurobehavioral recovery was assessed by three separate neurobehavioral tests including the modified neurological severity score (mNSS) (D), rotarod performance tests (e), and hanging wire tests (f, g), n = 15–20 per group. Data are presented as mean ± SD. *p < 0.05, ***p < 0.001