Fig. 4

FXR knockout prevented apoptosis after cerebral-ischemia. a Representative confocal images of NeuN⁺/TUNEL⁺ cells in the brain of peri-infarct area of sham mice (sham group), stroke mice treated with vehicle (vehicle group), and FXR knockout stroke mice (FXR KO group), Bar = 50 μm. n = 4–6 per group. ***p < 0.001. b Western blotting analysis of BCL-2, BAX, cleaved cascape-3, and CAMKII in the striatum of ipsilateral hemisphere of sham group, vehicle group, and FXR KO group at 3 days after stroke. n = 4–5 per group. *p < 0.05, **p < 0.01, ***p < 0.001