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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma

Fig. 2

Proinflammatory cytokines and NO levels in the medium of cerebral cortical and cerebellar microglias. Note that the concentrations of IL-1β, IL-6, TNF-α, and MCP-1 were raised in the media of cerebral cortical microglias (a1, b1) and cerebellar microglias (c1, d1) treated with sera or IgG in the OMS + NB group; consistently, the expression of nitric oxide (NO) was also enhanced in the media of cerebral cortical microglias (a2, b2) and cerebellar microglias (c2, d2) treated with sera or IgG in the OMS + NB group, whereas incubation with sera or IgG from children with only NB had no such effect (ad). **p < 0.01, ***p < 0.001, one-way ANOVA, n = 10 (health control), n = 20 (NB), n = 10 (OMS + NB)

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