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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma

Fig. 5

Neuronal cytolysis induced by conditioned media from cerebral cortical and cerebellar microglias. After microglias incubated with OMS + NB IgG, conditioned media were collected, got rid of the remaining IgG, and replaced the culture media of neurons. Note that preincubation with conditioned media from cerebral cortical and cerebellar microglias enhanced the cytolysis of neurons in the same brain regions (a, b) or exchanged brain regions (c, d), while no alteration was observed in the cytolysis of neurons incubated with conditional media from astrocytes (e, f). ***p < 0.001, one-way ANOVA, n = 10 (health control), n = 20 (NB), and n = 10 (OMS + NB)

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Journal of Neuroinflammation

ISSN: 1742-2094