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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Serum IgG-induced microglial activation enhances neuronal cytolysis via the NO/sGC/PKG pathway in children with opsoclonus-myoclonus syndrome and neuroblastoma

Fig. 7

The alleviation of neuronal cytolysis by pretreatment with pharmacological inhibitors of the NO cascade. Note that the cytolysis of cerebral cortical neurons (a) and cerebellar neurons (b) induced by conditioned media from microglias treated with OMS + NB IgG was relieved by the NO synthesis inhibitor 7-NINA, the cytolysis of cerebral cortical neurons (c) and cerebellar neurons (d) was reduced by the sGC inhibitor ODQ, and the cytolysis of cerebral cortical neurons (e) and cerebellar neurons (f) was abrogated by Rp-8Br-PET-cGMP, an inhibitor of PKG. ***p < 0.001, one-way ANOVA, n = 20 (vehicle, NB; inhibitor, NB), n = 10 (vehicle, OMS + NB; inhibitor, OMS + NB)

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Journal of Neuroinflammation

ISSN: 1742-2094