Fig. 3
From: Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Nlrp3 knockout enhances fear extinction and attenuates anxiety-like behavior. a Trial schematic for contextual fear memory paradigm, extinction training, and behavior tests. b Fear responses of 4 extinction training days. WT/Ctrl, n = 6; Nlrp3−/−/Ctrl, n = 6; WT/FS, n = 12; Nlrp3−/−/FS, n = 12. c Representative image of mice track plot in EPM test. d-f EPM test after 4 extinction trainings. WT/Ctrl, n = 7; Nlrp3−/−/Ctrl, n = 7; WT/FS, n = 15; Nlrp3−/−/FS, n = 15. g Representative image of mice track plot in OF test. h-j OF test after 4 extinction trainings. WT/Ctrl, n = 7; Nlrp3−/−/Ctrl, n = 7; WT/FS, n = 15; Nlrp3−/−/FS, n = 15. Data shown are mean ± SEM. Data were analyzed by one-way ANOVA (b), two-way ANOVA (b), and t test (d-f, h-j). NS, no significance; *p < 0.05; **p < 0.01; ***p < 0.001