Fig. 4
From: Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Administration of MCC950 enhances fear extinction and attenuates anxiety-like behavior. a Trial schematic for MCC950 administration (1 mg/kg), contextual fear memory paradigm, extinction training, and behavior tests. b Fear responses of 4 extinction training days. Saline/Ctrl, n = 4; MCC950/Ctrl, n = 4; saline/FS, n = 7; MCC950/FS, n = 12. c Representative image of mice track plot in EPM test. d-f EPM test after 4 extinction trainings. Saline/Ctrl, n = 8; MCC950/Ctrl, n = 8; saline/FS, n = 7; MCC950/FS, n = 9. g Representative image of mice track plot in OF test. h-j OF test after 4 extinction trainings. Saline/Ctrl, n = 8; MCC950/Ctrl, n = 8; saline/FS, n = 7; MCC950/FS, n = 9. Data shown are mean ± SEM. Data were analyzed by one-way ANOVA (b), two-way ANOVA (b), and t test (d-f, h-j). NS, no significance; *p < 0.05; **p < 0.01; ***p < 0.001