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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

Fig. 5

The NLRP3 inflammasome downstream cytokine IL-1β is involved in fear extinction. a Trial schematic for IL-1β (1 ng/kg) and IL-1ra (90 μg/kg) administration, contextual fear memory paradigm, extinction training, and behavior tests. b Fear responses of 4 extinction training days. Saline/Ctrl, n = 4; IL-1β/Ctrl, n = 4; IL-1ra/Ctrl, n = 6; saline/FS, n = 12; IL-1β/FS, n = 12; IL-1ra/FS, n = 12. c Representative image of mice track plot in EPM test. d-f EPM test after 4 extinction trainings. Saline/Ctrl, n = 6; IL-1β/Ctrl, n = 6; IL-1ra/Ctrl, n = 6; saline/FS, n = 6; IL-1β/FS, n = 6; IL-1ra/FS, n = 7. g Representative image of mice track plot in OF test. h-j OF test after 4 extinction trainings. Saline/Ctrl, n = 10; IL-1β/Ctrl, n = 10; IL-1ra/Ctrl, n = 9; saline/FS, n = 9; IL-1β/FS, n = 9; IL-1ra/FS, n = 10. Data shown are mean ± SEM. Data were analyzed by one-way ANOVA (b), two-way ANOVA (b) and t test (d-f, h-j). NS, no significance; *p < 0.05; **p < 0.01; ***p < 0.001

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