Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

Fig. 2

Ketamine administration rescued LPS-induced depression-like behaviors. a In OFT, there was no significant difference in total distance within 5 min among the four groups. b In the OFT, ketamine administration prevented LPS-induced decrease in time spent in the center and the number of entries into the center. c In the NSFT, ketamine administration prevented LPS-induced increase in feeding latency, and the total food consumption was not different among the four groups. d In the FST, ketamine administration prevented LPS-induced increase in immobility time. e Ketamine administration did not affect LPS-induced decrease in body weight change in the mice. f Ketamine administration improved the poor coat state of mice induced by LPS. Data are presented as mean ± SEM (n = 7–10 mice per group). *p < 0.05, **p < 0.01 vs the Sal + Sal group; ##p < 0.01 vs the LPS + Sal group. Sal, saline

Back to article page