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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

Fig. 3

Ketamine reversed LPS-induced extrasynaptic CaMKIIα activity in the hippocampus. The levels of CaMKIIα and p-CaMKIIα in extrasynaptic and synaptic fractions of the hippocampus were determined by western blotting. a Ketamine administration reversed LPS-induced increase in extrasynaptic p-CaMKIIα level in the hippocampus. b There was no significant difference in synaptic p-CaMKIIα level in the hippocampus among the four groups. Data are presented as mean ± SEM (n = 4–6 mice per group). *p < 0.05 vs the Sal + Sal group; #p < 0.05 vs the LPS + Sal group

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Journal of Neuroinflammation

ISSN: 1742-2094