Fig. 7

Ketamine reversed LPS-induced downregulation of p-CREB and BDNF expressions and the synaptic dysfunction in the hippocampus. a Ketamine administration blocked LPS-induced decrease in p-CREB expression in the hippocampus. b Ketamine administration blocked LPS-induced decrease in BDNF expression in the hippocampus. c Schematic representation of fEPSP before (gray) and after (black) HFS among the four groups. Horizontal calibration bars, 10 ms; vertical bars, 0.2 mV. Time course of fEPSP data normalized to the level of the 10-min baseline interval. Ketamine administration prevented LPS-induced depression of SC-CA1 LTP in the hippocampus. d, e Ketamine administration reversed LPS-induced decrease in GluR1 level but did not affect GluR2 level in the hippocampal synaptosomes. Data are presented as mean ± SEM (n = 4-7 mice per group). *p < 0.05 vs the Sal + Sal group; ^#p < 0.05, ^##p < 0.01 vs the LPS + Sal group