Fig. 8

JNK and P38 phosphorylation were restrained by CD200Fc after OGD in BV2 cells. CD200Fc inhibited phosphorylation of JNK (a, b) and P38 (a, c). Results are expressed as means ± SEM. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus the control group. ^**P < 0.05, ^**P < 0.01, ^***P < 0.001 versus the OGD+IgG group. CD200Fc reversed the phosphorylation of JNK (d, e) and P38 which induced by anisomycin (an agonist of JNK and P38) (d, f), n = 3. Results are expressed as means ± SEM. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus the control group. ^**P < 0.05, ^**P < 0.01, ^***P < 0.001 versus the anisomycin+IgG group.