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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice

Fig. 5

Effects of hippocampal Nlrp1a knockdown on BDNF levels in chronic stress-induced depressive-like mice. Representative immunoreactive bands and statistical results show that chronic stress decreased the protein expression of BDNF in hippocampus, while Nlrp1a knockdown restored BDNF expression in a CUMS mice (n = 4, F3,12 = 8.03, *P < 0.05 vs control, #P < 0.05 vs CUMS and control shRNA), b CRS mice (n = 4, F3,12 = 15.4, **P < 0.01, ***P < 0.001 vs control, ##P < 0.01 vs CRS and control shRNA), c RSDS mice (n = 4, F3,12 = 12.7, **P < 0.01, ***P < 0.001 vs control, #P < 0.05 vs RSDS and control shRNA) and d CSDS mice (n = 4, F3,12 = 10.2, *P < 0.05, **P < 0.01 vs control, #P < 0.05 vs CSDS and control shRNA). Data are expressed as means ± SEM. One-way ANOVA, Bonferroni test

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