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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice

Fig. 6

Effects of hippocampal Nlrp1a knockdown on the expression of CXCL1/CXCR2 in chronic stress-induced depressive-like mice. a–d Statistical results show that chronic stress increased the mRNA expression of CXCL1 in hippocampus, while Nlrp1a knockdown inhibited the effects in a CUMS mice (n = 4, F3,12 = 59.0, **P < 0.01, ***P < 0.001 vs control, ##P < 0.01 vs CUMS and control shRNA), b CRS mice (n = 4, F3,12 = 21.9, **P < 0.01, ***P < 0.001 vs control, ##P < 0.01 vs CRS and control shRNA), c RSDS mice (n = 4, F3,12 = 47.1, **P < 0.01, ***P < 0.001 vs control, ##P < 0.01 vs RSDS and control shRNA) and d CSDS mice (n = 4, F3,12 = 44.3, ***P < 0.001 vs control, ##P < 0.01 vs CSDS and control shRNA). e–h Statistical results show that chronic stress increased the mRNA expression of CXCR2 in hippocampus, while Nlrp1a knockdown inhibited the effects in e CUMS mice (n = 4, F3,12 = 23.2, **P < 0.01, ***P < 0.001 vs control, ##P < 0.01 vs CUMS and control shRNA), f CRS mice (n = 4, F3,12 = 12.4, **P < 0.01 vs control, #P < 0.05 vs CRS and control shRNA), g RSDS mice (n = 4, F3,12 = 20.1, **P < 0.01, ***P < 0.001 vs control, ##P < 0.01 vs RSDS and control shRNA), and h CSDS mice (n = 4, F3,12 = 22.1, ***P < 0.001 vs control, ##P<0.01 vs CSDS and control shRNA). Data are expressed as means ± SEM. One-way ANOVA, Bonferroni test

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