Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses

Gong, Lihong; Yu, Linyuan; Gong, Xiaohong; Wang, Cheng; Hu, Naihua; Dai, Xuyang; Peng, Cheng; Li, Yunxia

doi:10.1186/s12974-020-01855-9

Journal of Neuroinflammation

Table 2 Dysregulated proteins in different groups

From: Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO₄-induced inflammation in zebrafish by metabolomic and proteomic analyses

No.	Accession	Gene Symbol	Description	Control vs model	Model vs FA	Model vs FB
1	NP_001014348	srpx	Sushi repeat-containing protein SRPX precursor	↓^##	↑^**	↑^*
2	NP_001028768	mrps7	28S ribosomal protein S7, mitochondrial precursor	↑^###	↓^***	↓^***
3	NP_001077285	zgc:162509	Uncharacterized protein LOC553299	↑^##	↓^**	↓^**
4	NP_001268407	col2a1b	Collagen, type II, alpha 1b precursor	↑^##	↓^**	↓^***
5	NP_571742	gch2	GTP cyclohydrolase 1	↑^##	↓^***	↓^**
6	NP_942574	wdr3	WD repeat-containing protein 3	↑^##	↓^*	↓^*
7	NP_956140	ptpn11a	Tyrosine-protein phosphatase non-receptor type 11	↑^#	↓^*	↓^*
8	NP_956258	rcvrn2	Recoverin 2	↓^#	↑^**	↑^**
9	NP_991174	nit2	Omega-amidase NIT2	↑^#	↓^*	↓^*
10	NP_997744	col9a2	Collagen alpha-2(IX) chain precursor	↓^##	↑^***	↑^***
11	NP_998429	col9a1b	Collagen type IX alpha I precursor	↑^##	↓^**	↓^***
12	XP_021324964	nme3	Nucleoside diphosphate kinase 3 isoform X1	↑^###	↓^***	↓^***
13	XP_695887	scaf4a	Splicing factor, arginine/serine-rich 15	↓^#	↑^*	↑^**
14	NP_001002461	txn	Thioredoxin	↓^##	↑^*	─
15	NP_001003625	nup85	Nuclear pore complex protein Nup85	↑^#	↓^**	─
16	NP_001004660	snrpg	Small nuclear ribonucleoprotein G isoform 2	↓^#	↑^*	─
17	NP_001006043	ctsz	Cathepsin Z precursor	↓^#	↑^*	─
18	NP_001017899	capns1a	Calpain small subunit 1	↓^#	↑^**	─
19	NP_001019906	eif3m	Eukaryotic translation initiation factor 3 subunit M	↓^##	↑^**	─
20	NP_001020680	ppp6r2a	Serine/threonine-protein phosphatase 6 regulatory subunit 2	↑^##	↓^**	─
21	NP_001038800	rpl22l1	60S ribosomal protein L22-like 1	↓^###	↑^***	─
22	NP_001071203	bop1	Ribosome biogenesis protein bop1	↑^#	↓^**	─
23	NP_001082840	mrps30	39S ribosomal protein S30, mitochondrial	↓^#	↑^*	─
24	NP_001093210	matn1	Cartilage matrix protein precursor	↓^#	↑^***	─
25	NP_001096604	crygm2d16	Crystallin, gamma M2d16	↓^##	↑^***	─
26	NP_001103591	rps23	40S ribosomal protein S23	↓^#	↑^*	─
27	NP_001166027	bxdc2	Ribosome biogenesis protein BRX1 homolog	↑^##	↓^**	─
28	NP_001289671	atp5f1e	ATP synthase subunit epsilon, mitochondrial	↓^##	↑^**	─
29	NP_001338629	LOC100330864	Ribonucleoside-diphosphate reductase subunit M2 isoform 1	↑^#	↓^*	─
30	NP_571328	opn1mw1	Green-sensitive opsin-1	↓^##	↑^*	─
31	NP_956159	cdc42l	Cell division control protein 42 homolog	↓^#	↑^*	─
32	NP_956500	erap1b	Endoplasmic reticulum aminopeptidase 1 precursor	↓^#	↑^*	─
33	NP_957036	rps26l	Ribosomal protein S26	↓^#	↑^**	─
34	NP_957153	slc25a20	Mitochondrial carnitine/acylcarnitine carrier protein	↓^#	↑^**	─
35	NP_958493	pfn2	Profilin 2	↓^##	↑^*	─
36	NP_958500	arpc1a	Actin-related protein 2/3 complex subunit 1A	↓^#	↑^**	─
37	NP_963878	rpl12	60S ribosomal protein L12	↓^##	↑^*	─
38	NP_991317	psmd10	26S proteasome non-ATPase regulatory subunit 10	↓^#	↑^*	─
39	NP_997743	mcmbp	Mini-chromosome maintenance complex-binding protein	↓^##	↑^*	─
40	NP_997750	ist1	IST1 homolog isoform 1	↓^##	↑^***	─
41	NP_998569	lipf	Lysosomal acid lipase/cholesteryl ester hydrolase precursor	↓^#	↑^*	─
42	NP_998605	plrg1	Pleiotropic regulator 1	↑^##	↓^**	─
43	NP_999858	lgals3b	Galectin-3	↓^##	↑^***	─
44	NP_999977	epb41l3b	Erythrocyte membrane protein band 4.1-like 3b	↑^#	↓^*	─
45	XP_001923961	nxf1	Nuclear RNA export factor 1	↑^##	↓^*	─
46	XP_005159500	col11a2	Collagen alpha-2(XI) chain isoform X1	↓^##	↑^*	─
47	XP_005163206	tnni2a.4	Troponin I, skeletal, fast 2a.4 isoform X1	↑^##	↓^***	─
48	XP_017208249	coro6	Coronin-6 isoform X1	↓^#	↑^***	─
49	XP_021322373	arhgef1b	Rho guanine nucleotide exchange factor 1 isoform X1	↓^##	↑^**	─
50	XP_685270	sgca	Alpha-sarcoglycan	↑^#	↓^**	─
51	XP_691943	si:dkey-23a13.8	Histone H2B 1/2-like	↑^##	↓^**	─
52	NP_001019612	psma2	Proteasome alpha 2 subunit	↑^#	─	↓^*
53	NP_001071216	scg2b	Secretogranin-2 precursor	↓^##	─	↑^**
54	NP_001313480	si:dkey-251i10.2	si:dkey-251i10.2 precursor	↓^#	─	↑^*
55	NP_957419	spag7	Sperm-associated antigen 7 homolog	↑^#	─	↓^*
56	XP_005155974	si:ch211-222l21.1	Prothymosin alpha	↑^###	─	↓^**

↑, the protein was up-regulated; ↓, the protein was down-regulated
^#p < 0.05, ^##p < 0.01, ^###p < 0.001, compared with the control group
^*p < 0.05, ^**p < 0.01, ^***p < 0.001, compared with the model group

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ISSN: 1742-2094

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