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Table 1 General characteristics of the fructose-induced WKY rats

From: CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats

Parameter/groupControlFructose 2 weeksFructose 4 weeks
Systolic blood pressure, mmHg109.8 ± 1.8125.1 ± 2.2***144.5 ± 1.1***
Fasting serum glucose, mg/dL85.3 ± 1.8134.2 ± 4.9***147.0 ± 4.0***
Fasting serum triglyceride, mg/dL82.7 ± 1.2155.3 ± 18.6***177.8 ± 26.6***
Fasting serum dHDL, mg/dL83.0 ± 1.675.5 ± 4.5*71.5 ± 2.5*
Serum IL-1β, pg/mL27.93 ± 5.1349.97 ± 8.59*74.90 ± 7.07*
Serum IL-6, pg/mL3.44 ± 0.466.21 ± 0.24*10.02 ± 1.69*
Serum TNF-α, pg/mL25.82 ± 9.0574.06 ± 5.62*202.10 ± 17.82*
Serum fractalkine, ng/mL0.38 ± 0.060.36 ± 0.040.43 ± 0.05
CSF fractalkine, ng/mL1.20 ± 0.041.49 ± 0.07*1.65 ± 0.03*
NTS fractalkine, ng/mg4.06 ± 0.174.80 ± 0.36*5.98 ± 0.38*
NTS IL-1β, pg/mg6.53 ± 0.279.17 ± 0.32*12.63 ± 0.83*
NTS IL-6, pg/mg61.13 ± 6.30115.48 ± 3.30*150.87 ± 11.68*
NTSTNF-α, pg/mg1.15 ± 0.244.67 ± 0.75*12.17 ± 0.41*
  1. Levels of systolic blood pressure; fasting serum glucose; fasting serum triglycerides; fasting serum dHDL; and quantitative ELISA of serum, CSF, or NTS areas for FKN, IL-1β, IL-6, and TNF-α are presented as mean ± SEM. One-way ANOVA with Bonferroni’s post-hoc was performed for statistical analysis.
  2. *P < 0.05, ***P < 0.001 compared to control group (n = 6~8 per group)