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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism

Fig. 2

An HSD induces long-lasting hypersensitivity in mice, which is not reversible by returning to a ND. a Paw withdrawal thresholds were assessed using the von Frey test. Mechanical hypersensitivity was established on week 6 of HSD feeding and maintained until at least 3 months. n = 20–22/group. b After 3 months of HSD feeding, the diet regime was replaced by a ND for an additional 2 months, but their HSD-induced decreased mechanical thresholds remained low, n = 16–18/group. c Mechanical hypersensitivity was not reversible even as their diet regime was shifted back to ND after 1.5 months of HSD feeding, n = 14–18/group. Data were combined from male and female mice. All data were presented as mean ± SEM. Data were analyzed by two-way ANOVA followed by Bonferroni post-tests, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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