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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal

Fig. 7

Schematic presentation of the effects of rottlerin on the PMA-induced MMP-9 expression and astrocytic migration. In brain astrocytes (RBA cells), PMA induces ERK1/2 activation through PKC-δ and Nox-derived ROS signals resulting in c-Fos/AP-1-dependent MMP-9 expression. The increased MMP-9 leads to RBA cell migration. Rottlerin suppressed the PMA-induced MMP-9-related events (brain astrocytic migration) via reducing activation of PKC-δ, Nox/ROS, ERK1/2, and c-Fos/AP-1 signaling pathways

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Journal of Neuroinflammation

ISSN: 1742-2094