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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

Fig. 6

Molecular analysis of injured and treated brain tissue. ac Protein analysis at day 7 of brain from sham mice and mice injured (day 0) and treated on day 5 with either PBS, MSCs, or IL-4 MSCs; n = 5, N = 20. a Amount of interleukin-4 (IL-4) in ipsilateral and contralateral cortical samples, normalized to total protein present in the cortical sample, for each mouse group. b Amount of interleukin-6 (IL-6) in ipsilateral and contralateral cortical samples, normalized to total protein present in the cortical sample, for each mouse group. Graphs present mean ± SD; one-way ANOVA carried out for each with a post hoc Tukey’s comparison; *p < 0.05, **p < 0.01. c Gene analysis at 1 week or 3 weeks after injury and day 5 treatment with either PBS, MSCs, or IL-4 MSCs (n = 5) and sham mice as biological controls (n = 10); N = 40. c Heatmap of 13 select genes demonstrating up- (red) or down- (blue) regulation of genes with ΔΔCT values. Underlined values had a corrected p value < 0.05 as reported by the analysis tool

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