Fig. 6
From: Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE
Effects of rh-CSF1 on brain atrophy and neurological functions at 4 weeks post-HI. Rh-CSF1 treatment group showed significant improvement in the rotarod test (a), foot fault test (b), and spatial memory loss in terms of swimming less distance to find the platform (c) when compared with the vehicle. Rh-CSF1 treatment group also showed a decrease in escape latency (d), and more time spent in the target quadrant during the probe trial (e-f) when compared with the vehicle. f Representative picture of swim track in Probe Trial. Representative microphotograph of Nissl staining showed brain tissue loss in the ipsilateral hemisphere (g). Rh-CSF1 treatment significantly reduced brain weight loss and the percent of tissue loss (h-i) when compared with the vehicle. *P < 0.05 vs sham; #P < 0.05 vs vehicle. Data are represented as mean ± SD, n = 8 in each group