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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

Fig. 9

PLCG2 inhibitor U73122 abolished the anti-inflammatory effects of rh-CSF1 via CSF1R/PLCG2/PKCε/CREB signaling pathway at 48 h after HI. a Representative western blot bands. b–i Densitometric quantification of p-CSF1R, CSF1R, CSF1, p-PLCG2/PLCG2, p-PKCε/PKCε, p-CREB/CREB, IL-1β, and TNF-α in the ipsilateral hemisphere showed that U73122 significantly abolished the effects of rh-CSF1 treatment on protein levels of p-PLCG2, p-PKCε and p-CREB when administered with rh-CSF1. *P < 0.05 vs. sham; #P < 0.05 vs. HI+ Vehicle; @P < 0.05 vs. HI+ rh-CSF1 + DMSO; Data are represented as mean ± SD, n = 6 in each group

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