Fig. 1

Role of mineralocorticoid receptor (MR) specific antagonist canrenoate-K (Can) in the modulation of Freund’s complete adjuvant (FCA) inflammation-induced nociceptive behavior. a, b Four days FCA inflammation of the right hindpaw resulted in significantly reduced mechanical PPT thresholds compared to baseline values (dotted line) (P < 0.05, repeated measurement-ANOVA, followed by post-hoc Dunnett’s test; n = 6). Chronic i.t. canrenoate-K reversed this mechanical hypersensitivity (P < 0.05, repeated measurement-ANOVA, followed by post-hoc Dunnett’s test; n = 6). Data are expressed as means ± SD. b In contrast, i.t. administration of repetitive doses of the exogenous aldosterone resulted in significant PPT reductions compared to baseline (0 min) indicating a reduced mechanical nociceptive thresholds (hyperalgesia) ( P < 0.05, repeated measurement-ANOVA, followed by post-hoc Dunnett’s test; n = 6). Data are expressed as means ± SD