Fig. 3

MR selective antagonist canrenoate-K reversed the enhanced expression of pain signaling molecules TRPV1 (a), CGRP (b), Nav1.8 (c), and trkA (d) mRNA in nociceptive DRG neurons with inflammatory pain. a–d Chronic i.t. canrenoate-K administration to rats with Freund’s complete adjuvant (FCA)-induced inflammation reversed the enhanced expression of pain signaling molecules TRPV1 (a), CGRP (b), Nav1.8 (c), and trkA (d) mRNA. (P < 0.05, one-way ANOVA, followed by post-hoc Dunnett’s test, n = 10). Data are expressed as means ± SD