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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain

Fig. 4

MR selective antagonist canrenoate-K reversed the enhanced expression of pain signaling molecules TRPV1 (a), CGRP (b), Nav1.8 (c), and trkA (d) immunoreactivity in nociceptive DRG neurons with inflammatory pain. ad Chronic i.t. canrenoate-K administration to rats with Freund’s complete adjuvant (FCA)-induced inflammation reversed the increased number of pain signaling molecules TRPV1 (a), CGRP (b), Nav1.8 (c), and trkA (d) IR DRG neurons. (P < 0.05, one-way ANOVA, followed by post-hoc Dunnett’s test, n = 9–17) (Bar = 40 μm). Data are expressed as means ± SD

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