Fig. 2

Relationship between anti-JCV antibody serostatus and HLA class II alleles in Japanese MS patients. a Anti-JCV antibody-positive rates were compared between carriers and non-carriers of each HLA-DRB1 allele. The HLA-DRB1 allele was analyzed and is shown as 4 digits in the left panel and as 2 digits in the right panel. p values were obtained using Fisher’s exact test. b The relationships between anti-JCV antibody seropositivity rates and number of HLA-DRB1*15 or DRB1*04 alleles are shown. X in the figure indicates other alleles specified in each panel (other than DRB1*15 in the left panel and other than DRB1*04 in the middle and right panels). p values were obtained using the Cochran–Armitage trend test. c Anti-JCV antibody indices were compared between carriers and non-carriers of each HLA-DRB1 allele. HLA-DRB1 alleles were analyzed and are shown as 4 digits in the upper panels and as 2 digits in the lower panels. Boxes depict the median and interquartile ranges, and upper/lower whiskers extend from the hinge toward the largest/smallest values. p values were obtained using the Wilcoxon test. Ab = antibody; C = carriers; HLA = human leukocyte antigen; JCV = JC virus; MS = multiple sclerosis; non-C = non-carriers