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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway

Fig. 2

Metformin suppresses IA formation and progression in a rat model. A Representative images of cerebral arteries. HE and Masson’s trichrome staining show the destruction of vessel walls (arrow) in a rat model of IA. Scale bar = 50 μM. B Scanning electron micrographs of cerebral vessels; high magnification views reveal local bulging of vessels. Scale bar = 200 μM. C (a) Quantitative analysis of IAs in control, metformin, compound C, and metformin + compound C groups (n = 20/group). (b, c) Rate of aneurysm formation (b) and rupture (c) in different treatment groups (n = 20/group). #P < 0.05 vs 500 μM metformin group. (D) Changes in physiological parameters at indicated time points after IA induction. (a) Systolic pressure. (b, d) Serum Na+ (b) and K+ (d). (c) Blood glucose

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