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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Fig. 1

CH25H expression is increased in AD brain and AD transgenic mouse brain bearing amyloid or tau pathology. a, b Expression of CH25H at mRNA (a) or protein (b) levels in the brain tissue of AD patients vs age-matched non-demented controls. CH25H protein levels were normalized by β-actin with p = 0.06 (statistically analyzed using unpaired Student t test). c, d Expression of CH25H at mRNA (c) or protein (d) in APPPS1 transgenic mouse brain vs. age-matched non-tg littermates. e Quantification of d showing protein levels for CH25H, ASC, and NLRP3 by normalization to β-actin. f Expression of CH25H mRNA in PS19 tau P301S transgenic mouse brain vs non-tg littermates. g Expression of CH25H mRNA in TE2, TE3, TE4, and TEKO mouse brain. Statistical significance was determined by Student t test with *p < 0.05, **p < 0.01 or ***p < 0.005 in a, c, e, and f, or by ordinary one-way ANOVA with Dunnett’s multiple comparisons test **p < 0.01 in g

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