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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis

Fig. 2

Upregulated Lcn2 in brain is correlated with neuroinflammation A and B. Immunoreactivity of neuroinflammatory markers IL-6 (a) and IL-1β (b) proteins were shown by immunohistochemistry in brain slices (focused area is cerebral cortex) from mice fed with CHOW diet serves as a control and MCD diet (NASH). Immunoreactivity was indicated by black arrows. Images were taken at × 10 and × 20. Frontal cortex is marked as FC, and HC is hippocampus. c. Morphometric analysis of IL-6 and IL-1β was carried out as mean data from three separate microscopic fields (plotted on y-axis ) of CHOW and MCD fed mouse groups. Data were expressed as %ROI (mean ± SD, n = 3)

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