Fig. 1
From: TREM2 ectodomain and its soluble form in Alzheimer’s disease
Schematic representation of the human TREM2 gene and protein. TREM2 gene showing exonic (numbered boxes) and intronic (line) regions and sizes. The transcripts are shown with translated regions, and different colors represent different coding sequences of the transcription template. The three isoforms (ENST00000373113, ENST00000373122, and ENST00000338469) have the same exons 1, 2, and 3 coding regions but different exons 4 and 5 coding regions. ENST00000373122 contains a portion of the intronic sequence. The bottom panel shows the TREM2 protein, including the signal peptide (SP), immunoglobulin (Ig) domain, extracellular region (ETC), and transmembrane region (TM). Arrows represent α-secretase and γ-secretase cleavage sites, respectively. α-Secretase (ADAMs) cleaves TREM2 at His157−Ser158 site. R47H and R62H are two common AD-associated variants occurring in the Ig domain. aa, amino acid