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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis

Fig. 5

High-resolution ex vivo autoradiography of brain sections and spinal cord tissue further confirmed in vivo PET results. Ex vivo autoradiography (autorad) of (a) 40 μm-thick sagittal brain sections and (b) dissected whole spinal cords—cervical/thoracic (left) and lumbar (right). Nissl staining and photographs are shown for brain sections and spinal cords respectively. (c) Quantitation of radiotracer signal in brainstem, cerebellar white matter (WM), and spinal cord regions, expressed as mean pixel intensity divided by decay-corrected dose injected (MPI/dose); n = 4 per group for brainstem analysis (since brainstem was not successfully dissected for all mice), n = 5 per group for spinal cord analysis. *p = < 0.05, **p = < 0.01, ***p = < 0.001

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