Skip to main content

Table 1 Plasma biomarkers in patients with ASD and unaffected subjects

From: Oxidized cell-free DNA as a stress-signaling factor activating the chronic inflammatory process in patients with autism spectrum disorders

Parameters Healthy controls (n = 27) Patients with ASD
Detection limit Group I (n = 62) р1* Group II (n = 71) р1* р2**
cfDNA, ng/ml 25 ng/ml 389.4 ± 26
(151.8–732.6)
512.9 ± 197.8
(115.0–11338.0)
0.014 1151.2 ± 175.7
(78.7–4692.3)
< 0.001 < 0.001
Nuclease activity, U/ml 1 U/ml 8.6 ± 1.1
(3.3–29.2)
9.9 ± 1.0
(1.8–33.6)
0.599 10.4 ± 0.7
(4.4–30.7)
0.089 0.271
8-oxodG/106 deoxynucleosides 0.5/106deoxynucleosides 4.8 ± 0.9
(0.6–20.6)
3.3 ± 0.6
(0.5–20.6)
0.107 638.3 ± 313.2
(0.8–10478.9)
< 0.001 < 0.001
  1. Group I, the patients with mild-to-moderate ASD; group II, the patients with severe ASD. Data are presented as mean ± SEM (minimum valuemaximum value). The results were analyzed using Mann–Whitney U test. *p1, in comparison with healthy controls; **p2, in comparison with group I