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Table 1 Plasma biomarkers in patients with ASD and unaffected subjects

From: Oxidized cell-free DNA as a stress-signaling factor activating the chronic inflammatory process in patients with autism spectrum disorders

Parameters

Healthy controls (n = 27)

Patients with ASD

Detection limit

Group I (n = 62)

р1*

Group II (n = 71)

р1*

р2**

cfDNA, ng/ml

25 ng/ml

389.4 ± 26

(151.8–732.6)

512.9 ± 197.8

(115.0–11338.0)

0.014

1151.2 ± 175.7

(78.7–4692.3)

< 0.001

< 0.001

Nuclease activity, U/ml

1 U/ml

8.6 ± 1.1

(3.3–29.2)

9.9 ± 1.0

(1.8–33.6)

0.599

10.4 ± 0.7

(4.4–30.7)

0.089

0.271

8-oxodG/106 deoxynucleosides

0.5/106deoxynucleosides

4.8 ± 0.9

(0.6–20.6)

3.3 ± 0.6

(0.5–20.6)

0.107

638.3 ± 313.2

(0.8–10478.9)

< 0.001

< 0.001

  1. Group I, the patients with mild-to-moderate ASD; group II, the patients with severe ASD. Data are presented as mean ± SEM (minimum valuemaximum value). The results were analyzed using Mann–Whitney U test. *p1, in comparison with healthy controls; **p2, in comparison with group I