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Table 2 Plasma cytokine concentrations in patients with ASD and unaffected subjects

From: Oxidized cell-free DNA as a stress-signaling factor activating the chronic inflammatory process in patients with autism spectrum disorders

Plasma cytokines, pg/ml Healthy controls   Patients with ASD
  Detection limit Group I p1* Group II p1** p2***
IL-1β 3 pg/ml 0.1 ± 0.1
(0.0*–17.3) 		3.2 ± 1.6
(0.0–45.1) 		0.024 5.3 ± 1.6
(0.0–64.8) 		0.005 0.525
IL-8 10 pg/ml 726.8 ± 96.0
(171.4–5747.2) 		2401.6 ± 387.2
(314.7–7938.3) 		0.005 3966.0 ± 369.5
(238.0–8803.2) 		< 0.001 0.007
IL-17A 20 pg/ml 34.2 ± 19.6
(12.3–54.0) 		45.8 ± 20.1
(12.3–629.2) 		< 0.001 69.9 ± 22.5
(14.4–1019.3) 		< 0.001 0.022
IL-10 5 pg/ml 35.5 ± 7.1
(1.3–121.6) 		4.0 ± 0.6
(1.3–18.0) 		< 0.001 9.8 ± 3.9
(1.0–203.1) 		< 0.001 0.015
IFNγ 20 pg/ml 72.4 ± 16.2
(28.3–175.2) 		51.9 ± 29.8
(0.0–662.1) 		0.021 65.621.4
(0.0–825.4) 		0.151 0.014
  1. Group I, the patients with mild-to-moderate ASD; group II, the patients with severe ASD. Data are presented as mean ± SEM (minimum value–maximum value). * The data below the detectable limit were equated zero. The results were analyzed using nonparametric Mann–Whitney U test. **p1, in comparison with healthy controls; ***p2, in comparison with group I
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Journal of Neuroinflammation

ISSN: 1742-2094