Journal of Neuroinflammation

Table 2 Plasma cytokine concentrations in patients with ASD and unaffected subjects

From: Oxidized cell-free DNA as a stress-signaling factor activating the chronic inflammatory process in patients with autism spectrum disorders

Plasma cytokines, pg/ml		Healthy controls		Patients with ASD
	Detection limit	Healthy controls	Group I	p1*	Group II	p1**	p2***
IL-1β	3 pg/ml	0.1 ± 0.1 (0.0*–17.3)	3.2 ± 1.6 (0.0–45.1)	0.024	5.3 ± 1.6 (0.0–64.8)	0.005	0.525
IL-8	10 pg/ml	726.8 ± 96.0 (171.4–5747.2)	2401.6 ± 387.2 (314.7–7938.3)	0.005	3966.0 ± 369.5 (238.0–8803.2)	< 0.001	0.007
IL-17A	20 pg/ml	34.2 ± 19.6 (12.3–54.0)	45.8 ± 20.1 (12.3–629.2)	< 0.001	69.9 ± 22.5 (14.4–1019.3)	< 0.001	0.022
IL-10	5 pg/ml	35.5 ± 7.1 (1.3–121.6)	4.0 ± 0.6 (1.3–18.0)	< 0.001	9.8 ± 3.9 (1.0–203.1)	< 0.001	0.015
IFNγ	20 pg/ml	72.4 ± 16.2 (28.3–175.2)	51.9 ± 29.8 (0.0–662.1)	0.021	65.621.4 (0.0–825.4)	0.151	0.014

Group I, the patients with mild-to-moderate ASD; group II, the patients with severe ASD. Data are presented as mean ± SEM (minimum value–maximum value). * The data below the detectable limit were equated zero. The results were analyzed using nonparametric Mann–Whitney U test. **p1, in comparison with healthy controls; ***p2, in comparison with group I

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ISSN: 1742-2094

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