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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage

Fig. 8

Roles of the CX3CL1/CX3CR1 axis in SAH-induced early brain injury. MicroRNA-124 (miR-124) plays a vital role in microglial activation by targeting protein CCAAT-enhancer-binding protein α (C/EBPα). CX3CL1/CX3CR1 axis is involved in the delivery of miR-124 from neurons to microglia. The protein levels of CX3CL1/CX3CR1 were significantly reduced after SAH, accompanied by an increase in C/EBPα expression. CX3CL1/CX3CR1 axis may play a protective role after SAH by promoting the delivery of exosomal miR-124 from neurons to microglia to attenuate microglial activation and neuroinflammation

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