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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning

Fig. 2

Longitudinal results of TSPO μPET imaging and immunohistochemistry validation. a Age dependent exponential increase of 18 kDa translocator protein (TSPO) expression in different target regions of the brain of P301S tau model mice. n(P301S/WT) = 1.9 M, 33/18; 3.9 M, 32/17; 6.4 M, 29/17 (Mixed Model RM Anova of P301S vs wild-type per age). b Voxel-wise SPM analysis of TSPO expression in the contrast of P301S vs wild-type mice at different ages. T-score maps are projected upon an MRI template in sagittal and coronal slices. n equals to a. c Upper row: CD68 immunohistochemistry for the cortex and the brainstem of P301S mice and WT mice at 6.6 M. n(P301S/WT) = 13/5. Lower row: Time dependent increase of IBA1 immunohistochemistry for the cortex and the brainstem of P301S mice and WT mice. n(P301S/WT) = 2.7 M, 3/2; 4.8 M, 3/2; 6.6 M, 13/5. d Correlation plots of IBA1/CD68 immunohistochemistry and TSPO μPET at 6.4 months of age. n(CTX) = 12, n(BRST) = 11. M, months; OD, overall density; R, Pearson’s correlation coefficient; rS, Spearman’s correlation coefficient; CTX, cortex; BRST, brainstem; TG, transgenic P301S mice; WT, wild-type; *p < 0.05; **p < 0.01; ***p < 0.001. All error bars indicate SD

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