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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning

Fig. 3

Standardized comparison of time courses of microglial activation between tau and amyloid-β mouse models. ac Longitudinal TSPO expression in the cortex of tau and amyloid-β mouse models presented as z-score values against WT plotted with fitting as quadratic functions of age. d Standardized time courses of longitudinal TSPO expression in the cortex as expressed by the area under the curve (AUC) in three different mouse models. AUC values were normalized to the observation period and scaled by the z-score of the latest time point to control for absolute differences in TSPO expression of individual mice. eh Validation analysis in similar age ranges across all three models. AUC values of the validation analysis (h) were normalized to the observation period but not to the latest time point. P301S: n = 18 mice, 52 data points; AppNL-G-F: n = 21 mice, 68 data points; APP/PS1: n = 17 mice, 39 data points. Error bars of d and h indicate SD

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