Fig. 5

Associations of early and longitudinal microglial activation with outcome parameters. a Correlation of longitudinal TSPO expression in P301S mice (expressed as %-increase between 1.9 and 6.4 months of age) with accumulation of AT8 positive tau accumulation in IHC for the cortex and the brainstem; n = 14. b Correlation of combined longitudinal TSPO expression in cortex and hippocampus (calculated as AUC) with terminal MWM performance; n = 18. c Correlations of early and longitudinal TSPO expression (BL z-score and %-increase) with terminal glucose metabolism (FDG PET z-score) for the cortex and the hippocampus; n = 24