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Table 1 Overview on μPET and immunohistochemistry (IHC) results

From: Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning

Mouse strain Age (months) PET (n) TSPO CTX TSPO HIP TSPO BRST TSPO CBL Age (months) IHC (n) IBA1 CTX IBA1 BRST CD 68 CTX CD68 BRST AT8 CTX AT8 BRST
P301S 1.9 33 0.64 ± 0.07 0.90 ± 0.06 0.96 ± 0.07 0.86 ± 0.07 2.7 3 0.19 ± 0.04 0.18 ± 0.01 2.63 ± 0.76 4.12 ± 0.12
3.9 32 0.70 ± 0.07 0.93 ± 0.07*** 0.99 ± 0.07** 1.06 ± 0.10 4.8 3 0.25 ± 0.05 0.20 ± 0.04 3.70 ± 0.89 4.56 ± 0.04
6.4 29 0.85 ± 0.05*** 1.05 ± 0.04*** 1.28 ± 0.08*** 1.31 ± 0.07*** 6.6 14 0.49 ± 0.08** 0.38 ± 0.05** 0.31 ± 0.03* 0.36 ± 0.05* 5.57 ± 1.27 5.50 ± 0.95
WT 2.1 18 0.62 ± 0.07 0.88 ± 0.06 0.97 ± 0.07 0.90 ± 0.09 2.7 2 0.19 ± 0.01 0.20 ± 0.02
4.1 17 0.67 ± 0.05 0.87 ± 0.04 0.94 ± 0.04 1.03 ± 0.07 4.5 2 0.21 ± 0.01 0.21 ± 3E-4
6.5 17 0.76 ± 0.05 0.95 ± 0.03 1.05 ± 0.04 1.11 ± 0.05 6.7 5 0.35 ± 0.04 0.25 ± 0.03 0.28 ± 0.02 0.29 ± 0.03 0 0
P301S Age (months) PET (n) FDG CTX FDG HIP FDG BRST FDG CBL         
  6.4 24 0.78 ± 0.05 0.90 ± 0.03*** 1.17 ± 0.04** 1.03 ± 0.05         
WT 6.1 16 0.75 ± 0.05 0.95 ± 0.05 1.22 ± 0.05 1.04 ± 0.05         
  1. PET values are reported as SUVRNAC. p values were calculated by two-way t test or Mann Whitney U test of P301S vs age-matched wild-type (WT) mice
  2. FDG18F-Fluorodesoxyglucose, CTX cortex, HIP hippocampus, BRST brainstem, CBL cerebellum
  3. *p < 0.05, **p < 0.01, ***p < 0.001