Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model

Fig. 7

LRCH1 knockdown worsens tissue damage and locomotor function after SCI. a H&E staining of spinal cords on day 7 after SCI. Sham-saline, sham-operated rats injected with saline. LC, rats receiving LC-infected microglia. LL, rats receiving LL-infected microglia. The arrow indicates the tissue deficit probably caused by saline injection. b, c Double staining of TUNEL and NeuN in T12 on day 7 after SCI. Representative fluorescent images are shown in b. Please note that the green color of NeuN is a pseudocolor added by the imaging software, because Alexa Fluor 647 is a far-red fluorescent dye invisible to the eyes. Statistics for the proportions of TUNEL+NeuN+ cells in NeuN+ cells was shown in c. n = 3 in 3 independent experiments. d BBB scores. n = 8. e mRNA levels of indicated cytokines in T12 on day 7 after SCI. n = 6 in 3 independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094