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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Fig. 1

A schematic representation of the operation and administration timeline in rats. a Rats were anesthetized and inserted a guide cannula into the right lateral ventricle. After 7 days, the rats received trace fear conditioning (TFC) training, and then drugs were injected into the right lateral ventricle through the implanted guide cannula. Rats were given exploratory laparotomy 30 min later, and tests were carried out 1 day after laparotomy. b A schematic representation of the TFC procedure in rats. In the TFC training part, the rats first explored 100 s, and then experienced three cycles of stimulation: 20 s of sound stimulation (yellow), 2 s of electrical stimulation (red), and 100 s of interval (grey). In the TFC test part, freezing behaviour in the absence of the tone and shock was automatically scored over the course of 300 s

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